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CabezaLab — Laboratory at Duke University focused on the cognitive neuroscience of memory and aging — Page 2

Using behavioral and neuroimaging methods, we investigate the cognitive and neural mechanisms of memory and emotion and how they change across the lifespan.

  Emotion processing has been shown to vary with age: relative to young adults (YAs), older adults (OAs) exhibit increased frontal activations to emotional materials as well as cognitive biases toward positive versus negative stimuli. This latter effect is hypothesized to depend on OAs’ capacity for controlled elaboration. To test this hypothesis, YAs and OAs […]

Whereas ventral mPFC (medial prefrontal cortex) has been associated with inferences about one’s own self, dorsal mPFC has been associated with inferences about others. We investigated this distinction using a novel camera technology that automatically takes hundreds of photographs when worn. We fMRI-scanned young participants while viewing movie clips depicting events from their own life […]

Many studies in our lab focus on the fact that, as we age, our brains start to use two hemispheres when our younger selves used just one. This phenomenon, called contralateral recruitment, remains controversial because its neural correlates are still poorly understood. To investigate this phenomenon, we used a lateralized word-matching paradigm that emphasized either […]

Major depressive disorder (MDD) is characterized by the presence of disturbances in emotional processing and its associated neural responses. A critical question in this domain is whether the neural correlates of these alterations are affected by therapeutic interventions. This study used fMRI to compare neural responses to emotionally positive, negative, and neutral pictures in patients […]

Older adults recall less episodically rich autobiographical memories (AM), however, the neural basis of this effect is not clear.  Using functionalMRI, we examined the neural correlates supporting memory retrieval while young and older adults searched for and elaborated upon AMs.  Our results suggest that the age-related attenuation in the episodic richness of AMs is associated […]

According to the Attention to Memory (AtoM) model, dorsal parietal cortex (DPC) mediates top-down attention processes guided by retrieval goals, whereas ventral parietal cortex (VPC) mediates bottom-up attention processes captured by the retrieval output or the retrieval cue. This model also hypothesizes that the attentional functions of DPC and VPC are similar for memory and […]

As we age, our brains change quite dramatically and shrinking in size and changing in composition. We conducted a study to examine one rather overlooked element of this changing composition, mainly the idea that myelin—the sheaths around our nerve cells keeping everything running smoothly—degenerate as we age. In order to study this we used diffusion […]