Using behavioral and neuroimaging methods, we investigate the cognitive and neural mechanisms of memory and emotion and how they change across the lifespan.

The reliable neuroimaging finding that older adults often show greater activity (over-recruitment) than younger adults is typically attributed to compensation. Yet, advice the neural mechanisms of over-recruitment in older adults (OAs) are largely unknown. Rodent electrophysiology studies have shown that as number of afferent fibers within a circuit decreases with age, search the fibers that remain show higher synaptic field […]

   Although it is well established that the perirhinal cortex (PRC) makes an important contribution to recognition memory, the specific nature of this contribution remains uncertain. The finding that PRC activity is reduced for old compared to new items is typically attributed to the recovery of a long-term memory signal. However, because old items are […]

The present investigation tested the novel prediction that encoding-retrieval similarity can be observed and related to memory at the level of individual items. Multivariate representational similarity analysis was applied to functional magnetic resonance imaging (fMRI) data collected during encoding and retrieval of emotional and neutral scenes. Memory success tracked fluctuations in encoding-retrieval similarity across frontal and posterior cortices. Importantly, medicine […]

Although ventral parietal cortex (VPC) activations can be found in a variety of cognitive domains, recipe these activations have been typically attributed to cognitive operations specific to each domain. In this article, we propose a hypothesis that can account for VPC activations across all the cognitive domains reviewed. We first review VPC activations in the domains of perceptual and […]

Roberto Cabeza gave the keynote address Feb. 29 at the University of Florida McKnight Brain Institute symposium on aging, memory and cognitive decline. Dr. Cabeza’s talk discussed the idea that older brains work in different ways to complete the same tasks as younger brains. See the news article here.

If you read Japanese, click see here or this poster for details on the March 3rd talk in Tsukuba. Roberto Cabeza is one of the Organizers, and will speak for, the Gakushuin International Symposium in Tokyo on March 4th.

Studies of cognitive and neural aging have recently provided evidence of a shift from an early- to late-onset cognitive control strategy, troche linked with temporally extended activity in the prefrontal cortex (PFC). It has been uncertain, however, whether this age-related shift is unique to PFC and executive control tasks, or whether the functional location might […]

Aging is associated with both decreases and increases in brain activity. Whereas age-related decreases usually reflect neural decline, seek some age-related increases have been linked to functional compensation. Compensatory activations in older adults (OAs) are typically found in the prefrontal cortex (PFC) but in the memory domain we have also found them in the temporal […]

Episodic Retrieval Processes

November 28, 2011

We investigate the neural mechanisms of various episodic retrieval processes, link including recovery processes associated with MTL, medical control processes associated with PFC, and support processes associated with PFC and posterior parietal cortices (PPC). Recovery refers to the access of stored memory traces, in the form of specific contextual details (recollection) or in the form […]

Aging is associated with significant decline in the integrity of white matter (WM), and this decline contributes to age-related deficits in cognitive functions such as memory. WM integrity can be measured in vivo using diffusion tensor imaging (DTI). DTI assesses MR changes due to the movement of water molecules, which are more parallel in intact […]