Basic Memory Mechanisms

Functional neuroimaging studies have associated episodic memory with activations in medial temporal lobe (MTL), illness prefrontal cortex (PFC), posterior parietal cortex (PPC), and other brain regions (Cabeza et al., 2008; Cabeza & Nyberg, 2000; Dew & Cabeza, 2011).  We investigae the contributions of these regions and their subregions to different memory encoding and retrieval processes. For more information, click on the projects listed on the  right.

  • Cabeza, R., Ciaramelli, E., Olson, I. R., Moscovitch, M. (2008). Parietal Cortex and Episodic Memory: An Attentional Account. Nature Reviews Neuroscience, 9, 613-625. 
  • Cabeza, R., & Nyberg, L. (2000). Neural basis of learning and memory: Functional neuroimaging evidence. Current Opinion in Neurology, 13, 415-421.
  • Dew, I. T., Cabeza, R. (2011). The porous boundaries between explicit and implicit memory: Behavioral and neural evidence. Annals of the New York Academy of Sciences, 1224, 174-190. 

Emotional Memory

Emotion can enhance or impair memory processes (Dolcos et al., 2006; LaBar & Cabeza, 2006). The modulatory effect of emotion on memory may reflect direct effects of the  amygdala (i.e., an emotion region) on the MTL memory system (i.e., a memory region) or indirect effects mediated by attentional, working memory, and semantic processes mediated by PFC and parietal regions.  We investigate these effects both during encoding and during retrieval. For more information, click on the projects listed on the  right.

  • Dolcos, F., LaBar, K. S., & Cabeza, R. (2006). The memory-enhancing effect of emotion: Functional neuroimaging evidence. In B. Uttl, N. Ohta, & A. L. Siegenthaler (Eds.), Memory and emotion: Interdisciplinary perspectives (pp. 107-134)Malden, MA: Blackwell Publishing. 
  • LaBar, K. S., & Cabeza, R. (2006). Cognitive neuroscience of emotional memory. Nature Reviews Neuroscience, 7, 54-64. 

Cognitive Aging

The goal of the new discipline of cognitive neuroscience of aging  (Cabeza, Nyberg, & Park, 2004) is to reveal the neural mechanisms of age-related changes in cognition (Dennis & Cabeza,  2008). At a broader level, we investigate age-related compensatory mechanisms shared across cognitive domains (Cabeza & Dennis, in press), and white matter changes, measured with DTI (Davis et al., 2008), that have a general impact on cognition . At the domain level, we investigate age effects on the neural mechanisms of memory  (Daselaar & Cabeza, in press) and emotion (St. Jacques et al., in press). For more information, click on the projects listed on the  right.

  • Cabeza, R. & Dennis, N.A. (in press). Frontal lobes and aging: Deterioration and compensation. In D.T. Stuss & R.T. Knight  (Eds). Principles of Frontal Lobe Function, 2nd Edition. Oxford University Press, New York.
  • Cabeza, R., Nyberg, L., Park, D. C. (2004). Cognitive Neuroscience of Aging: Linking Cognitive and Cerebral Aging. Oxford University Press.
  • Daselaar, S.M., Cabeza, R., (in press). Age-related decline in working memory and episodic memory: contributions of PFC and MTL. In S. Kosslyn & K. Ochsner (Eds) Oxford Handbook of Cognitive Neuroscience. Oxford University Press.
  • Davis, S. W., Kragel, J. Madden, D.J., & Cabeza, R. (2011). Cross-hemispheric communication and aging:  Linking behavior, brain activity, functional connectivity, and white matter integrity. Cerebral Cortex
  • Dennis, N. A., & Cabeza, R. (2008). Neuroimaging of healthy cognitive aging. In F. I. M. Craik & T. A. Salthouse (Eds.), Handbook of aging and cognition: Third editionMahwah, NJ: Erlbaum. 
  • St. Jacques, P.L., Winecoff, A., & Cabeza, R. (in press). Emotion and ageing. In P. Vuilleumier, & J. Armony (Eds). Handbook of Human Affective Neuroscience. Cambridge University Press, Cambridge, UK